Effect of Obesity on Pharmacokinetics and Biologic Effect of Interferon-alpha in Hepatitis C

@article{Pharmd1997EffectOO,
  title={Effect of Obesity on Pharmacokinetics and Biologic Effect of Interferon-alpha in Hepatitis C},
  author={Nancy P. Lam Pharmd and David L. Pitrak and Rita Speralakis Pharmd and Alan H. Lau Pharmd and Thelma E. Wiley and Thomas J. Layden},
  journal={Digestive Diseases and Sciences},
  year={1997},
  volume={42},
  pages={178-185}
}
To examine potential adverse effects of obesityin reducing the response to interferon-alpha (IFN-alpha)in chronic hepatitis C (HCV), IFN-alpha and HCV RNAlevels in serum and the 2′,5′-oligoadenylatesynthetase (2-5 OAS) levels in peripheral bloodmononuclear cells (PBMC) were compared between six obeseand five nonobese patients before and after a single, 10mIU dose of IFN-alpha2b. There were nodifferences in the mean histologic activity index between thetwo groups. The maximal IFN concentration… CONTINUE READING

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Signi® cance of serum hepatitis C virus RNA levels in chronic hepatitis

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