Effect of Obesity on Oocyte and Embryo Quality in Women Undergoing In Vitro Fertilization

  title={Effect of Obesity on Oocyte and Embryo Quality in Women Undergoing In Vitro Fertilization},
  author={Divya Kelath Shah and Stacey A. Missmer and Katharine F. Berry and Catherine Racowsky and Elizabeth Ginsburg},
  journal={Obstetrics \& Gynecology},
OBJECTIVE: To estimate the effect of body mass index (BMI) on oocyte and embryo parameters and cycle outcomes in women undergoing in vitro fertilization (IVF). METHODS: We evaluated a retrospective cohort of 1,721 women undergoing a first IVF cycle with fresh, autologous embryos between 2007 and 2010 in an academic infertility practice. Main outcome measures included number of mature and normally fertilized oocytes, embryo morphology, estradiol on the day of human chorionic gonadotropin… 

The impact of maternal body mass index on in vitro fertilization outcomes.

Obesity adversely impacts the number and maturity of oocytes in conventional IVF not in minimal stimulation IVF

The data suggest that mild ovarian stimulation might yield healthier oocytes in obese women, and that female adiposity might impair oocyte number and maturity in conventional IVF but not in mini-IVF.

Effect of weight status on pregnancy outcome in intra cytoplasmic sperm injection

A BMI cut off value of above 26 kg/m2 in the study population is associated with a negative impact on pregnancy outcome.

A Comprehensive Analysis of Body Mass Index Effect on in Vitro Fertilization Outcomes

Evaluating the effects of female BMI on number and quality of retrieved oocytes, fertilization rate, embryo score and incidences of ongoing pregnancy and live births among couples undergoing IVF in an Italian population found no differences across different BMI categories.

Obesity results with smaller oocyte in in vitro fertilization/intracytoplasmic sperm injection cycles—a prospective study

Obesity is associated with smaller oocytes, which adversely affect fertility outcomes, and larger oolema diameter was positively associated with the probability of pregnancy in the obese group as well as thinner zona pellucida.

Correlation of body mass index with outcome of in vitro fertilization in a developing country

This study shows that poorer oocyte quality is seen with increasing BMI which results in reduced CPR, and female obesity impairs IVF outcome potentially by impairing oocytes quality but does not affect ovarian response to stimulation.

Maternal underweight does not adversely affect the outcomes of IVF/ICSI and frozen embryo transfer cycles or early embryo development

  • D. HoffmanY. Kalma H. Amir
  • Medicine
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • 2022
Underweight status has no adverse impacts on the outcomes of IVF/ICSI with either fresh or frozen ET or on preimplantation embryo development and quality.

The Role of Overweight and Obesity in In Vitro Fertilization Outcomes of Poor Ovarian Responders

Despite similar counts of recruited mature oocytes, obese POR women had decreased fertilization and clinical pregnancy rates and obesity rather than overweight significantly decreased IVF outcomes in POR.



Does Body Mass Index of Infertile Women Have an Impact on IVF Procedure and Outcome?

Both underweight and overweight have negative effects on IVF parameters and outcome leading to decreased chances of pregnancy.

Obstetric Outcomes After In Vitro Fertilization in Obese and Morbidly Obese Women

There is a significantly higher risk for IVF cycle cancellation in morbidly obese patients with no effect of BMI on clinical pregnancy or delivery rate, however, obese and morbidly obesity subjects had a significantlyHigher risk for obstetric complications.

Female obesity adversely affects assisted reproductive technology (ART) pregnancy and live birth rates.

Higher BMI is associated with an increased failure to achieve a clinical intrauterine gestation; this risk was overcome with the use of donor oocytes, and failure to achieved a live birth increased with increasing obesity, to a greater extent among women <35 years of age.