Effect of ORF119 gene deletion on the replication and virulence of orf virus.

@article{Qiao2015EffectOO,
  title={Effect of ORF119 gene deletion on the replication and virulence of orf virus.},
  author={Jun Qing Qiao and Ho Bin Yang and You Liang Peng and Qing-li Meng and Cai Fang Chen and Yufang Ma and Kun Xie and Tiffany L. Liu and Xiao Peng Cai},
  journal={Acta virologica},
  year={2015},
  volume={59 3},
  pages={257-64}
}
Orf is a severe infectious disease of sheep and goats caused by orf virus (ORFV). To investigate the role of ORF119 gene of ORFV, we constructed ORFV with deleted ORF119 gene and LacZ as reporter gene (ORFV-Δ119-LacZ) via homologous recombination. The results showed that wild-type ORF-SHZ1 and ORFV-Δ119-LacZ deletion viruses replicated in Vero cells to… CONTINUE READING