Effect of OPC-12759 on EGF receptor activation, p44/p42 MAPK activity, and secretion in conjunctival goblet cells.

@article{Ros2008EffectOO,
  title={Effect of OPC-12759 on EGF receptor activation, p44/p42 MAPK activity, and secretion in conjunctival goblet cells.},
  author={Jos{\'e} David R{\'i}os and Marie A. Shatos and Hiroki Urashima and Darlene Ann Dartt},
  journal={Experimental eye research},
  year={2008},
  volume={86 4},
  pages={629-36}
}
The purpose of the study was to determine if OPC-12759 stimulates secretion from conjunctival goblet cells in culture and if it activates the EGF receptor (EGFR) and p44/p42 mitogen-activated protein kinase (MAPK) to cause mucin secretion. Conjunctival goblet cells were cultured from pieces of male rat conjunctiva. OPC-12759 was added at increasing concentrations and for varying times to the cultured cells. The cholinergic agonist carbachol was used as a positive control. In selected… CONTINUE READING

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