Effect of Nucleus Basalis Magnocellularis Ablation on Local Brain Glucose Utilization in the Rat: Functional Brain Reorganization.


After unilateral destruction of the nucleus basalis magnocellularis (NBM) in 3-month-old rats, which reduces cholinergic inputs to the ipsilateral frontoparietal neocortex, regional cerebral metabolic rates for glucose (rCMRglc) of denervated cortex are initially reduced, but nearly normalize by 2 weeks. To examine functional reorganization of the brain… (More)


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