• DOI:10.1023/A:1022634112815
• Corpus ID: 142803

Effect of Nooglutil on Benzodiazepine Withdrawal Syndrome and Binding of 3H-Spiperone with D2 Receptors in Rat Striatum

@article{Voronina2004EffectON,
  title={Effect of Nooglutil on Benzodiazepine Withdrawal Syndrome and Binding of 3H-Spiperone with D2 Receptors in Rat Striatum},
  author={T. A. Voronina and G G Borlikova and T. L. Garibova and T.V. Proskuryakova and O. B. Petrichenko and S. G. Burd and G. N. Avakyan},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2004},
  volume={134},
  pages={448-450}
}

• T. Voronina, G. Borlikova, +4 authors G. Avakyan
• Published 1 November 2002
• Biology, Medicine
• Bulletin of Experimental Biology and Medicine

A new nootropic preparation nooglutil (N-(5-oxynicotinoyl)-L-glutamic acid), a positive modulator of AMPA receptors for glutamate, administered intraperitoneally in a dose of 70 mg/kg reduced anxiety of rats in the Vogel conflict test after 24-h withdrawal from chronic diazepam treatment (4 mg/kg intraperitoneally for 45 days). Nooglutil (5 nM-750 μM) had no effect on in vitro binding of 3H-spiperone in intact rats. Systemic administration of 50 mg/kg nooglutil in vivo increased the dissociation constant and density of D2 receptors. Increasing the dose to 100 mg/kg abolished this effect. Our findings suggest that nooglutil produces an indirect effect on the brain dopaminergic system under normal and pathological conditions and this effect is probably mediated via the glutamatergic system.