Effect of Nooglutil on Benzodiazepine Withdrawal Syndrome and Binding of 3H-Spiperone with D2 Receptors in Rat Striatum

  title={Effect of Nooglutil on Benzodiazepine Withdrawal Syndrome and Binding of 3H-Spiperone with D2 Receptors in Rat Striatum},
  author={T. A. Voronina and G G Borlikova and T. L. Garibova and T.V. Proskuryakova and O. B. Petrichenko and S. G. Burd and G. N. Avakyan},
  journal={Bulletin of Experimental Biology and Medicine},
A new nootropic preparation nooglutil (N-(5-oxynicotinoyl)-L-glutamic acid), a positive modulator of AMPA receptors for glutamate, administered intraperitoneally in a dose of 70 mg/kg reduced anxiety of rats in the Vogel conflict test after 24-h withdrawal from chronic diazepam treatment (4 mg/kg intraperitoneally for 45 days). Nooglutil (5 nM-750 μM) had no effect on in vitro binding of 3H-spiperone in intact rats. Systemic administration of 50 mg/kg nooglutil in vivo increased the… 


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