Effect of Nitrous Oxide on Folate and Vitamin B12 Metabolism in Patients

@article{Koblin1990EffectON,
  title={Effect of Nitrous Oxide on Folate and Vitamin B12 Metabolism in Patients},
  author={D. Koblin and B. W. Tomerson and F. Waldman and G. H. Lampe and L. Wauk and E. Eger},
  journal={Anesthesia & Analgesia},
  year={1990},
  volume={71},
  pages={610–617}
}
  • D. Koblin, B. W. Tomerson, +3 authors E. Eger
  • Published 1990
  • Medicine
  • Anesthesia & Analgesia
  • Exposure to nitrous oxide (N2O) markedly enhances excretion of formic acid and formiminoglutamic acid (FIGLU) in the urine of rats, suggesting a disruption in the normal pathways of folic acid metabolism secondary to an N2O-induced inactivation of methionine synthase. We tested whether surgical patients (23 having total hip replacements and 26 having resection of acoustic neuromas) exposed to isoflurane alone or combined with N2O responded similarly. We found no increase in urinary formic acid… CONTINUE READING
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    • 2003
    • 87
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    • 1
    • Highly Influenced
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    • 234
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    • PDF
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    • 1
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    • 8
    • PDF
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    • 27

    References

    SHOWING 1-10 OF 29 REFERENCES
    Effect of nitrous oxide on serum vitamin-B12 levels under surgical anesthesia.
    • 4
    Urinary folate loss following inactivation of vitamin B12 by nitrous oxide in rats
    • 28
    Increased urinary excretion of formiminoglutamic acid in nitrous-oxide-treated rats and its reduction by methionine.
    • 12
    • Highly Influential
    Clinical aspects of the interaction between nitrous oxide and vitamin B12.
    • J. Nunn
    • Medicine
    • British journal of anaesthesia
    • 1987
    • 217
    • PDF
    Nitrous Oxide Inactivates Methionine Synthetase in Human Liver
    • 112
    MEGALOBLASTIC HÆMOPOIESIS IN PATIENTS RECEIVING NITROUS OXIDE
    • 265
    Clinical Pharmacology of Nitrous Oxide: An Argument for Its Continued Use
    • 83
    Dimethylthiourea, a hydroxyl radical scavenger, impedes the inactivation of methionine synthase by nitrous oxide in mice.
    • 19