• DOI:10.1213/00000539-199012000-00007
Corpus ID: 13536219

Effect of Nitrous Oxide on Folate and Vitamin B12 Metabolism in Patients

@article{Koblin1990EffectON,
  title={Effect of Nitrous Oxide on Folate and Vitamin B12 Metabolism in Patients},
  author={D. Koblin and B. W. Tomerson and F. Waldman and G. H. Lampe and L. Wauk and E. Eger},
  journal={Anesthesia & Analgesia},
  year={1990},
  volume={71},
  pages={610–617}
}

D. Koblin, B. W. Tomerson, +3 authors E. Eger

Published 1990

Medicine

Anesthesia & Analgesia

Exposure to nitrous oxide (N2O) markedly enhances excretion of formic acid and formiminoglutamic acid (FIGLU) in the urine of rats, suggesting a disruption in the normal pathways of folic acid metabolism secondary to an N2O-induced inactivation of methionine synthase. We tested whether surgical patients (23 having total hip replacements and 26 having resection of acoustic neuromas) exposed to isoflurane alone or combined with N2O responded similarly. We found no increase in urinary formic acid… CONTINUE READING

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