Effect of Nigella sativa and Fenugreek on the pharmacokinetics and pharmacodynamics of amlodipine, in hypertensive rats.

  title={Effect of Nigella sativa and Fenugreek on the pharmacokinetics and pharmacodynamics of amlodipine, in hypertensive rats.},
  author={Mohd Aftab Alam and Yousef A. Bin Jardan and Mohammad Raish and Abdullah Mohammed Al-Mohizea and Abdul Ahad and Fahad Ibrahim Al-Jenoobi},
  journal={Current drug metabolism},
BACKGROUND Present article is related to in-vitro and in-vivo herb-drug interaction studies. OBJECTIVES To investigate the effect of Nigella sativa and fenugreek on the pharmacodynamics and pharmacokinetics of amlodipine. METHOD Hypertensive rats of group-I were treated with amlodipine; and of group-II and III were treated with N. sativa, and N. sativa + amlodipine; and fenugreek, and fenugreek + amlodipine; respectively. Systolic blood pressure (SBP), diastolic blood pressure (DBP) and… 
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