Effect of Nicotine on Dopamine and Glutathione Levels in Presence of Oligoelements in Brain Regions of Young Rats——Effect of Nicotine on Brain Regions of Rat

  title={Effect of Nicotine on Dopamine and Glutathione Levels in Presence of Oligoelements in Brain Regions of Young Rats——Effect of Nicotine on Brain Regions of Rat},
  author={David Calder{\'o}n Guzm{\'a}n and Ernestina Hern{\'a}ndez Garc{\'i}a and Francisca Trujillo Jim{\'e}nez and Gerardo Barrag{\'a}n Mej{\'i}a and Hugo Ju{\'a}rez Olgu{\'i}n and Jos{\'e} A. Saldivar Gonz{\'a}lez and Daniel Santamar{\'i}a del Angel and Norma Osnaya Brizuela},
  journal={Neuroscience and Medicine},
Aim: The purpose of this study was to understand the mechanism of nicotine mediated addiction and the role of oligoelements in reducing its effect. Methods: Male Wistar rats (weight 80 g) were treated with single and repeated doses of nicotine and/or oligoelements as follows: group 1 (control) NaCl 0.9%; group 2, nicotine (1 mg/kg); group 3, oligoelements (50 μl/rat); and group 4, nicotine (1 mg/kg) + oligoelements (50 μl/rat). All drugs were intraperitoneally administered for 4 days. Blood for… Expand
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