Effect of Neuroligin1 and Neurexin1 on the Colonic Motility in a Mouse Model of Neuronal Intestinal Dysplasia

  title={Effect of Neuroligin1 and Neurexin1 on the Colonic Motility in a Mouse Model of Neuronal Intestinal Dysplasia},
  author={Dongming Wang and N. Gao and Tingting Zhou and Qiangye Zhang and J. Wang and Aiwu Li},
  journal={Gastroenterology Research and Practice},
Aim To investigate the expressions of neuroligin1 (NL1) and neurexin1 (NX1) in a mouse model of neuronal intestinal dysplasia (Tlx2−/− mice) and to explore their effects on colonic motility. Methods Immunohistochemistry staining was employed to explore the histological appearances of NL1, NX1, the presynaptic marker of glutamatergic synapses VGLUT1, and the subunit of NMDA receptors of NR1 in the colon of mice with or without Tlx2 mutation. Western blotting and qRT-PCR were performed to detect… Expand
2 Citations


Expression of neurexin and neuroligin in the enteric nervous system and their down-regulated expression levels in Hirschsprung disease
Abundance and Significance of Neuroligin-1 and Neurexin II in the Enteric Nervous System of Embryonic Rats
Transcriptional regulation of TLX2 and impaired intestinal innervation: possible role of the PHOX2A and PHOX2B genes
Intestinal neuronal dysplasia-like pathology in Ncx/Hox11L.1 gene-deficient mice.
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