Effect of Nedocromil Sodium on Bronchoconstriction Induced by Adenosine and Tachykinins

@article{Pauwels1989EffectON,
  title={Effect of Nedocromil Sodium on Bronchoconstriction Induced by Adenosine and Tachykinins},
  author={Dr R. Pauwels and Guy Joos and M. Van Der Straeten},
  journal={Drugs},
  year={1989},
  volume={37},
  pages={87-93}
}
SummaryPurines and neuropeptides may act as neurotransmitters of the local axon reflex in the airways. Nedocromil sodium has been shown to inhibit adenosine- and neurokinin A-induced bronchoconstriction both in the rat and in man. In this study we used the rat model for further investigation of the mechanism of action of nedocromil sodium in the adenosine- and neurokinin A-challenge. The animals were challenged intravenously, and immediately after maximal bronchoconstriction a bronchoalveolar… CONTINUE READING

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Airways Smooth Muscle: Neurotransmitters, Amines, Lipid Mediators and Signal Transduction

  • Respiratory Pharmacology and Pharmacotherapy
  • 1995
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