Effect of Natalizumab on Circulating CD4+ T-Cells in Multiple Sclerosis

  title={Effect of Natalizumab on Circulating CD4+ T-Cells in Multiple Sclerosis},
  author={Lars B{\"o}rnsen and Jeppe Romme Christensen and Rikke Lenhard Ratzer and Annette Bang Oturai and Per Soelberg S\orensen and Helle Bach S\ondergaard and Finn Thorup Sellebjerg},
  booktitle={PloS one},
In multiple sclerosis (MS), treatment with the monoclonal antibody natalizumab effectively reduces the formation of acute lesions in the central nervous system (CNS). Natalizumab binds the integrin very late antigen (VLA)-4, expressed on the surface of immune cells, and inhibits VLA-4 dependent transmigration of circulating immune-cells across the vascular endothelium into the CNS. Recent studies suggested that natalizumab treated MS patients have an increased T-cell pool in the blood… CONTINUE READING
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