Effect of Natalizumab Treatment on Circulating Plasmacytoid Dendritic Cells: A Cross-Sectional Observational Study in Patients with Multiple Sclerosis

@inproceedings{Kiviskk2014EffectON,
  title={Effect of Natalizumab Treatment on Circulating Plasmacytoid Dendritic Cells: A Cross-Sectional Observational Study in Patients with Multiple Sclerosis},
  author={Pia Kivis{\"a}kk and Katiana Francois and Julvet Mbianda and Roopali Gandhi and Howard L. Weiner and Samia J Khoury},
  booktitle={PloS one},
  year={2014}
}
OBJECTIVES Dendritic cells (DCs) serve a critical role both in promoting and inhibiting adaptive immunity. The goal of this study was to investigate the effect of natalizumab (NTZ) treatment on DC numbers, phenotype, and function in patients with multiple sclerosis (MS). METHODS Frequency and phenotype of myeloid and plasmacytoid DCs (MDCs and PDCs, respectively) were analyzed in blood from two separate cohorts of untreated, interferon-treated, or NTZ-treated MS patients. In addition, PDCs… CONTINUE READING
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