Effect of NPC15199 on [Ca²⁺]i and viability in SCM1 human gastric cancer cells.

@article{Cheng2016EffectON,
  title={Effect of NPC15199 on [Ca²⁺]i and viability in SCM1 human gastric cancer cells.},
  author={He-Hsiung Cheng and C T Chou and Wei-Zhe Liang and Jin‐shiung Cheng and Hong‐Tai Chang and Chun‐Chi Kuo and I-shu Chen and Ti Lu and C.-C. Yu and Fu-An Chen and Daih Huang Kuo and Pochuen Shieh and C-R Jan},
  journal={The Chinese journal of physiology},
  year={2016},
  volume={59 5},
  pages={
          268-275
        }
}
NPC15199 is a synthesized compound that inhibits inflammation in some models. However, whether NPC15199 affects Ca²⁺ homeostasis in human gastric cancer is unclear. This study examined the effect of NPC15199 on cytosolic free Ca²⁺ concentrations ([Ca²⁺]i) and viability in SCM1 human gastric cancer cells. The Ca²⁺-sensitive fluorescent dye fura-2 was used to measure [Ca²⁺]i. NPC15199 evoked [Ca²⁺]i rises concentration-dependently. The response was reduced by removing extracellular Ca²⁺. NPC15199… 

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