• Corpus ID: 32871783

Effect of NPC-15199 on Ca2+ levels in renal tubular cells.

@article{Jan2002EffectON,
  title={Effect of NPC-15199 on Ca2+ levels in renal tubular cells.},
  author={C-R Jan and Bang Ping Jiann and Hong‐Tai Chang and Changsong Yu and Yih-Chau Lu and J H Yeh and Wei-C Chen and Y P Law and Jong‐Khing Huang},
  journal={The Chinese journal of physiology},
  year={2002},
  volume={45 3},
  pages={
          117-22
        }
}
In Madin-Darby canine kidney (MDCK) cells, effect of NPC-15199 on intracellular Ca2+ concentration ([Ca2+]i) was investigated by using fura-2. NPC-15199 (100-1000 microM) caused a rapid and sustained increase of [Ca2+]i in a concentration-dependent manner (EC50=500 microM). NPC-15199-induced [Ca2+]i rise was prevented by 70% by removal of extracellular Ca2+, but was not changed by dihydropyridines, verapamil and diltiazem. In Ca2+-free medium, carbonylcyanide m-chlorophenylhydrazone (CCCP; 2… 
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