Effect of NMDA NR2B antagonist on neuropathic pain in two spinal cord injury models

@article{Kim2012EffectON,
  title={Effect of NMDA NR2B antagonist on neuropathic pain in two spinal cord injury models},
  author={Youngkyung ‘Claire’ Kim and Hwi-young Cho and Young Ju Ahn and June-sun Kim and Young Wook Yoon},
  journal={PAIN®},
  year={2012},
  volume={153},
  pages={1022-1029}
}
N-Methyl-d-aspartate (NMDA) receptors are thought to play an important role in the processes of central sensitization and pathogenesis of neuropathic pain, particularly after spinal cord injury (SCI). NMDA antagonists effectively reduce neuropathic pain, but serious side effects prevent their use as therapeutic drugs. NMDA NR2B antagonists have been reported to effectively reduce inflammatory and neuropathic pain. In this study, we investigated the effects of NR2B antagonists on neuropathic… CONTINUE READING

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