Effect of NMDA NR2B antagonist on neuropathic pain in two spinal cord injury models

  title={Effect of NMDA NR2B antagonist on neuropathic pain in two spinal cord injury models},
  author={Youngkyung ‘Claire’ Kim and Hwi-young Cho and Young Ju Ahn and June-sun Kim and Young Wook Yoon},
N-Methyl-d-aspartate (NMDA) receptors are thought to play an important role in the processes of central sensitization and pathogenesis of neuropathic pain, particularly after spinal cord injury (SCI). NMDA antagonists effectively reduce neuropathic pain, but serious side effects prevent their use as therapeutic drugs. NMDA NR2B antagonists have been reported to effectively reduce inflammatory and neuropathic pain. In this study, we investigated the effects of NR2B antagonists on neuropathic… CONTINUE READING


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Taxonomy and epidemiology of spinal cord injury pain. Spinal cord injury pain: assessment, mechanisms, management

PJ Siddall, RP Yezierski, JD Loeser, KJ. Burchiel
View 4 Excerpts
Highly Influenced


S Boyce, A Wyatt, +6 authors NM Rupniak

Spinal Cord Injury Pain: Spinal and Supraspinal Mechanisms

Journal of rehabilitation research and development • 2009
View 3 Excerpts

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