Effect of N-acetylcysteine on plasma cysteine and glutathione following paracetamol administration

@article{Burgunder1989EffectON,
  title={Effect of N-acetylcysteine on plasma cysteine and glutathione following paracetamol administration},
  author={Jean Marc Burgunder and Antonio Varriale and Bernhard H. Lauterburg},
  journal={European Journal of Clinical Pharmacology},
  year={1989},
  volume={36},
  pages={127-131}
}
SummaryThe effect of oral N-acetyl-L-cysteine (NAC) on plasma sulphhydryls has been studied in healthy volunteers.Following NAC 30 mg·kg−1, total NAC in plasma (i.e. free NAC and NAC as disulphides) reached a median peak concentration of 67 nmol·ml−1 within 45 to 60 min, and disappeared with an apparent half-life of 1.3 h. Only a fraction of total NAC (AUC 163 nmol·ml−1·h) was in the form of free NAC (AUC 12 nmol·ml−1·h, peak concentration 9 nmol·ml−1). Free cysteine was markedly increased… CONTINUE READING

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