Corpus ID: 386691

Effect of N-acetylcysteine on heat shock protein induction by acetaminophen in mouse liver.

@article{Salminen1998EffectON,
  title={Effect of N-acetylcysteine on heat shock protein induction by acetaminophen in mouse liver.},
  author={W. Salminen and R. Voellmy and S. Roberts},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1998},
  volume={286 1},
  pages={
          519-24
        }
}
It was previously shown that a necrogenic dose of acetaminophen (APAP) induced the 25- and 70-kDa heat shock proteins (hsp25 and hsp70i) in mouse liver, whereas nonnecrogenic doses failed to alter the level of either hsp. A strong correlation between the intralobular sites of APAP arylation of protein and hsp induction suggested that APAP-induced protein denaturation may play a role in triggering hsp induction. This study was conducted to determine whether APAP arylation of protein without… Expand
Heat shock protein 70 induction and its urinary excretion in a model of acetaminophen nephrotoxicity
Effect of N-acetylcysteine on acetaminophen toxicity in mice: relationship to reactive nitrogen and cytokine formation.
Attenuating Oxidative Stress by Paeonol Protected against Acetaminophen-Induced Hepatotoxicity in Mice
Genomics and proteomics analysis of acetaminophen toxicity in mouse liver.
Cell culture model for acetaminophen-induced hepatocyte death in vivo.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 42 REFERENCES
Differential heat shock protein induction by acetaminophen and a nonhepatotoxic regioisomer, 3'-hydroxyacetanilide, in mouse liver.
Effects of N-acetylcysteine on acetaminophen covalent binding and hepatic necrosis in mice.
Heat shock protein induction in murine liver after acute treatment with cocaine
Oxidative stress in cultured hepatocytes exposed to acetaminophen.
Stress protein synthesis induced in rat liver by cadmium precedes hepatotoxicity.
Acetaminophen-induced hepatotoxicity. Analysis of total covalent binding vs. specific binding to cysteine.
Oxidative stress by acute acetaminophen administration in mouse liver.
...
1
2
3
4
5
...