Effect of N,N-dimethyl-p-methoxyphenylethylamine on blood pressure and brain catecholamines in DOCA-saline hypertensive rats.

Abstract

Intraperitoneal and intraventricular injections of N,N-dimethyl-p-methoxyphenyl ethylamine (PMPEA) decreased blood pressure in conscious DOCA-saline hypertensive rats. Bilateral injection of this agent into the nucleus tractus solitarii (NTS) of anaesthetized normotensive rats also caused a decrease in blood pressure. The increased turnover of noradrenaline in the dorsal part of the caudal medulla oblongata in DOCA-saline hypertensive rats was found to be restored to normal following treatment with N,N-dimethyl PMPEA. The data indicate a central site of action for the antihypertensive effect of N,N-dimethyl PMPEA.

Cite this paper

@article{Shalita1982EffectON, title={Effect of N,N-dimethyl-p-methoxyphenylethylamine on blood pressure and brain catecholamines in DOCA-saline hypertensive rats.}, author={Benyamin Shalita and Dirk H. G. Versteeg and Wybren De Jong}, journal={European journal of pharmacology}, year={1982}, volume={85 2}, pages={229-32} }