Effect of Mycobacterium tuberculosis and its components on macrophages and the release of matrix metalloproteinases.

@article{Chang1996EffectOM,
  title={Effect of Mycobacterium tuberculosis and its components on macrophages and the release of matrix metalloproteinases.},
  author={Jenghwa Chang and A. Wysocki and Kam Meng Tchou-Wong and N Moskowitz and Yuping Zhang and William Rom},
  journal={Thorax},
  year={1996},
  volume={51 3},
  pages={306-11}
}
BACKGROUND Pulmonary tuberculosis is associated with caseating necrosis, parenchymal lung destruction, and cavity formation. It was hypothesised that tuberculous lung destruction is mediated, at least in part, by the participation of matrix metalloproteinases released by mononuclear phagocytes. METHODS Cells of the myelomonocytic leukaemia cell line THP-1 were incubated with lipoarabinomannan (LAM), the major antigenic cell wall component, and with Mycobacterium tuberculosis and analysed by… CONTINUE READING
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