Effect of Methylene Blue and Related Redox Dyes on Monoamine Oxidase Activity; Rat Pineal Content of N‐Acetylserotonin, Melatonin, and Related Indoles; and Righting Reflex in Melatonin‐Primed Frogs

@article{Oxenkrug2007EffectOM,
  title={Effect of Methylene Blue and Related Redox Dyes on Monoamine Oxidase Activity; Rat Pineal Content of N‐Acetylserotonin, Melatonin, and Related Indoles; and Righting Reflex in Melatonin‐Primed Frogs},
  author={G. Oxenkrug and S. Sablin and P. Requintina},
  journal={Annals of the New York Academy of Sciences},
  year={2007},
  volume={1122}
}
  • G. Oxenkrug, S. Sablin, P. Requintina
  • Published 2007
  • Chemistry, Medicine
  • Annals of the New York Academy of Sciences
  • The ability of methylene blue (MB) to inhibit the nitric oxide–induced stimulation of N‐methyl‐d‐aspartate receptors has been suggested as a possible mechanism of MB's clinical antidepressant action. This study evaluated the alternative/additional mechanisms of the antidepressant effect of MB on biochemical and behavior levels. Selective inhibition of monoamine oxidase type A (MAO‐A) is widely accepted as a major mechanism of the clinical antidepressant effect. MB and the related redox dyes… CONTINUE READING
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