Effect of Methylene Blue and Related Redox Dyes on Monoamine Oxidase Activity; Rat Pineal Content of N‐Acetylserotonin, Melatonin, and Related Indoles; and Righting Reflex in Melatonin‐Primed Frogs

@article{Oxenkrug2007EffectOM,
  title={Effect of Methylene Blue and Related Redox Dyes on Monoamine Oxidase Activity; Rat Pineal Content of N‐Acetylserotonin, Melatonin, and Related Indoles; and Righting Reflex in Melatonin‐Primed Frogs},
  author={G. Oxenkrug and S. Sablin and P. Requintina},
  journal={Annals of the New York Academy of Sciences},
  year={2007},
  volume={1122}
}
  • G. Oxenkrug, S. Sablin, P. Requintina
  • Published 2007
  • Chemistry, Medicine
  • Annals of the New York Academy of Sciences
    • The ability of methylene blue (MB) to inhibit the nitric oxide–induced stimulation of N‐methyl‐d‐aspartate receptors has been suggested as a possible mechanism of MB's clinical antidepressant action. This study evaluated the alternative/additional mechanisms of the antidepressant effect of MB on biochemical and behavior levels. Selective inhibition of monoamine oxidase type A (MAO‐A) is widely accepted as a major mechanism of the clinical antidepressant effect. MB and the related redox dyes… CONTINUE READING
    View on Wiley
    ncbi.nlm.nih.gov
    23 Citations
    Highly Influential Citations
    3
    Background Citations
    11
    Results Citations
    1
    23 Citations
    Citation Type

    Citation Type

    The monoamine oxidase inhibition properties of selected structural analogues of methylene blue
    • 13
    Role of monoamine oxidase, nitric oxide synthase and regional brain monoamines in the antidepressant-like effects of methylene blue and selected structural analogues.
    • 65
    • PDF
    Monoamine oxidase inhibition by selected dye compounds
    Inhibition of the bioactivation of the neurotoxin MPTP by antioxidants, redox agents and monoamine oxidase inhibitors.
    • T. Herraiz, H. Guillen
    • Chemistry, Medicine
    • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
    • 2011
    • 26
    • Highly Influenced
    • PDF
    Methylene blue and its analogues as antidepressant compounds
    • 19
    Repurposing an established drug: an emerging role for methylene blue in L‐DOPA‐induced dyskinesia
    • 2
    • Highly Influenced
    Cellular and molecular actions of Methylene Blue in the nervous system
    • 185
    Methyl Yellow: A Potential Drug Scaffold for Parkinson's Disease
    • 4
    • PDF
    Methylene blue and Alzheimer's disease.
    • 195
    N-acetylserotonin and aging-associated cognitive impairment and depression.
    • 20

    References

    SHOWING 1-10 OF 28 REFERENCES
    Evidence that the neuronal nitric oxide synthase inhibitor 7-nitroindazole inhibits monoamine oxidase in the rat: in vivo effects on extracellular striatal dopamine and 3,4-dihydroxyphenylacetic acid
    • 10
    The neuronal nitric oxide synthase inhibitor 7-nitroindazole also inhibits the monoamine oxidase-B-catalyzed oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
    • 98
    The effect of nifedipine, Ca(2+) antagonist, on activity of MAO inhibitors, N-acetylserotonin and melatonin in the mouse tail suspension test.
    • 39
    • PDF
    Antidepressive and antihypertensive effects of MAO-A inhibition: role of N-acetylserotonin. A review.
    • 19
    Serotonergic mediation of the antidepressant-like effects of nitric oxide synthase inhibitors
    • 150
    Endogenous nitric oxide decreases hippocampal levels of serotonin and dopamine in vivo
    • 168
    Synergistic sedative effect of selective MAO-A, but not MAO-B, inhibitors and melatonin in frogs.
    • 5
    Melatonin exerts an antidepressant-like effect in the tail suspension test in mice: evidence for involvement of N-methyl-d-aspartate receptors and the l-arginine-nitric oxide pathway
    • 181
    • PDF
    Reduction of cGMP and nitric oxide has antidepressant-like effects in the forced swimming test in rats
    • 131
    Inhibition of nitric oxide synthesis by methylene blue.
    • 473
    • PDF