• DOI:10.3181/00379727-93-22757
Corpus ID: 22939197

Effect of Methotrexate Therapy upon Choriocarcinoma and Chorioadenoma

@article{Li1956EffectOM,
  title={Effect of Methotrexate Therapy upon Choriocarcinoma and Chorioadenoma},
  author={M. C. Li and R. Hertz and Donald B. Spencer},
  journal={Proceedings of the Society for Experimental Biology and Medicine},
  year={1956},
  volume={93},
  pages={361 - 366}
}

M. C. Li, R. Hertz, Donald B. Spencer

Published 1956

Medicine

Proceedings of the Society for Experimental Biology and Medicine

Summary 1) Two patients with choriocarcinoma and one with chorioadenoma destruens with proven progressive metastases were treated with methotrexate, a folic acid antagonist, according to intensive regimen of repeated courses of dosages producing substantial but reversible toxicity. Initially high urinary gonadotropin present in all 3 cases approached normal levels following this regimen and such low levels were sustained following cessation of treatment. 2) Unequivocal clinical improvement and… CONTINUE READING

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