Effect of Methotrexate Therapy upon Choriocarcinoma and Chorioadenoma

@article{Li1956EffectOM,
  title={Effect of Methotrexate Therapy upon Choriocarcinoma and Chorioadenoma},
  author={M. C. Li and R. Hertz and Donald B. Spencer},
  journal={Proceedings of the Society for Experimental Biology and Medicine},
  year={1956},
  volume={93},
  pages={361 - 366}
}
  • M. C. Li, R. Hertz, Donald B. Spencer
  • Published 1956
  • Medicine
  • Proceedings of the Society for Experimental Biology and Medicine
  • Summary 1) Two patients with choriocarcinoma and one with chorioadenoma destruens with proven progressive metastases were treated with methotrexate, a folic acid antagonist, according to intensive regimen of repeated courses of dosages producing substantial but reversible toxicity. Initially high urinary gonadotropin present in all 3 cases approached normal levels following this regimen and such low levels were sustained following cessation of treatment. 2) Unequivocal clinical improvement and… CONTINUE READING
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