Effect of Melatonin on Doxorubicin Induced Testicular Damage in Rats

@inproceedings{Patil2009EffectOM,
  title={Effect of Melatonin on Doxorubicin Induced Testicular Damage in Rats},
  author={Sushama D. Patil and Ramachandran Balaraman},
  year={2009}
}
The protective effect of melatonin against doxorubicin induced testicular toxicity was investigated in male rats. Melatonin was administered orally to rats at a dose of 6 mg/kg daily for 28 days along with doxorubicin. Doxorubicin was administered intraperitoneally to the animals at a dose of 3mg/kg once a week for 5 weeks (a total of 15mg/kg) on day 1, 7,14,21,28. Treatment with doxorubicin alone caused decrease in body weight, sperm count and serum testosterone and increase in serum levels of… CONTINUE READING
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