Effect of Megestrol Caproate on the Reproductive Function of Laboratory Animals

@article{Pirzada2004EffectOM,
  title={Effect of Megestrol Caproate on the Reproductive Function of Laboratory Animals},
  author={O. Pirzada},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2004},
  volume={133},
  pages={574-576}
}
  • O. Pirzada
  • Published 1 June 2002
  • Chemistry, Medicine
  • Bulletin of Experimental Biology and Medicine
In vivo experiments on rats and rabbits showed that megestrol caproate, a 17-alpha-hydroxyprogesterone derivative exhibits 10-fold higher gestagenic activity compared to progesterone and possesses no androgenic, anabolic, and estrogenic activities. 

References

ESTROGEN ASSAYS USING THE RAT UTERUS1
TLDR
The utility of immature rat uteri as an end-point for the quantitative bioassay of estrogens using both the subcutaneous and oral routes of administration and to study the relative oral activity of various estrogen sulfates is studied.