Effect of Mahonia aquifolium active compounds on interleukin-8 production in the human monocytic cell line THP-1.

@article{Hajnick2002EffectOM,
  title={Effect of Mahonia aquifolium active compounds on interleukin-8 production in the human monocytic cell line THP-1.},
  author={V. Hajnick{\'a} and D. Kost{\'a}lov{\'a} and D. {\vS}vecov{\'a} and R. Sochorov{\'a} and N. Fuchsberger and J. T{\'o}th},
  journal={Planta medica},
  year={2002},
  volume={68 3},
  pages={
          266-8
        }
}
  • V. Hajnická, D. Kostálová, +3 authors J. Tóth
  • Published 2002
  • Medicine
  • Planta medica
  • The effect of the crude extract and of two alkaloid fractions prepared from Mahonia aquifolium on interleukin-8 (IL-8) production in the lipopolysaccharide (LPS)-stimulated human monocytic cell line THP-1 was studied. The production of IL-8 by cells stimulated with 20 ng/ml LPS after 48 h treatment with 20 microg/ml crude extract was inhibited by about 30 %. LPS-stimulated cells treated with 0.1 microg/ml bisbenzylisoquinoline alkaloid fraction exhibited a 40% inhibition of IL-8 production in… CONTINUE READING
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