Effect of Macitentan on the Development of New Ischemic Digital Ulcers in Patients With Systemic Sclerosis: DUAL-1 and DUAL-2 Randomized Clinical Trials.

@article{Khanna2016EffectOM,
  title={Effect of Macitentan on the Development of New Ischemic Digital Ulcers in Patients With Systemic Sclerosis: DUAL-1 and DUAL-2 Randomized Clinical Trials.},
  author={Dinesh Khanna and Christopher P. Denton and Peter A. Merkel and Thomas M. Krieg and Franck-Olivier Le Brun and Angelina Marr and Kelly Papadakis and Janet Elizabeth Pope and Marco Matucci-Cerinic and Daniel e. Furst},
  journal={JAMA},
  year={2016},
  volume={315 18},
  pages={1975-88}
}
IMPORTANCE Digital ulcers in patients with systemic sclerosis are associated with pain and poor quality of life. Endothelin-1 promotes vasculopathy in systemic sclerosis after macitentan, an endothelin-1 blocker. OBJECTIVE To evaluate the efficacy of macitentan in reducing the number of new digital ulcers in patients with systemic sclerosis. DESIGN… CONTINUE READING