Effect of MTII on food intake and brain c-Fos in melanocortin-3, melanocortin-4, and double MC3 and MC4 receptor knockout mice.

Abstract

Mice with genomic knockout of either melanocortin type 3 receptors (MC3R-/-), type 4 receptors (MC4R-/-) or knockout of both (double knockout, DKO) were tested for their anorectic response to the mixed MC3/4R agonist, MTII, injected into the anterior cerebral ventricle. Wild type (WT) mice showed a strong anorexia and, as expected, DKO were completely… (More)
DOI: 10.1016/j.peptides.2010.08.016

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Cite this paper

@article{Rowland2010EffectOM, title={Effect of MTII on food intake and brain c-Fos in melanocortin-3, melanocortin-4, and double MC3 and MC4 receptor knockout mice.}, author={Neil E. Rowland and Jay W Schaub and Kimberly L. Robertson and Amy Andreasen and Carrie Haskell-Luevano}, journal={Peptides}, year={2010}, volume={31 12}, pages={2314-7} }