Effect of MS-153 on the development of behavioral sensitization to locomotion- and ataxia-inducing effects of phencyclidine

@article{Abekawa2002EffectOM,
  title={Effect of MS-153 on the development of behavioral sensitization to locomotion- and ataxia-inducing effects of phencyclidine},
  author={T. Abekawa and M. Honda and K. Ito and T. Inoue and T. Koyama},
  journal={Psychopharmacology},
  year={2002},
  volume={160},
  pages={122-131}
}
Abstract. Rationale: Repeated administration of phencyclidine (PCP) produces behavioral sensitization to PCP. Although the precise mechanism is unknown, glutamatergic neurotransmission seems to play an important role in the development of sensitization. Objectives: The present study examined whether a novel compound, MS-153 ((R)-(–)-5-methyl-1-nicotinyl-2-pyrazoline), which has an ability to enhance glutamate uptake and inhibit glutamate release, would block the development of behavioral… Expand
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