Effect of MPTP on dopaminergic neurons in the goldfish brain: a light and electron microscope study.

@article{Goping1995EffectOM,
  title={Effect of MPTP on dopaminergic neurons in the goldfish brain: a light and electron microscope study.},
  author={Gertrud Goping and Harvey B Pollard and O M Adeyemo and Gemma A. J. Kuijpers},
  journal={Brain research},
  year={1995},
  volume={687 1-2},
  pages={35-52}
}
The neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) causes a Parkinsonian syndrome in the goldfish (Carassius auratus), characterized by transient bradykinesia, the accumulation of MPP+ in the brain, and a decrease in the forebrain and midbrain content of catecholamines (Pollard et al., FASEB J., 6 (1992) 3108-3116). Using light and electron microscopy, we studied the effect of MPTP on the distribution and ultrastructure of tyrosine hydroxylase (TH)-immunoreactive, dopaminergic… CONTINUE READING

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