Effect of MHC class I diversification on influenza epitope-specific CD8+ T cell precursor frequency and subsequent effector function.

Abstract

Earlier studies of influenza-specific CD8(+) T cell immunodominance hierarchies indicated that expression of the H2K(k) MHC class I allele greatly diminishes responses to the H2D(b)-restriced D(b)PA(224) epitope (acid polymerase, residues 224-233 complexed with H2D(b)). The results suggested that the presence of H2K(k) during thymic differentiation led to… (More)
DOI: 10.4049/jimmunol.1000883

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