Effect of Licofelone—A Dual COX/5-LOX Inhibitor in Intracerebroventricular Streptozotocin-Induced Behavioral and Biochemical Abnormalities in Rats

@article{Kumar2014EffectOL,
  title={Effect of Licofelone—A Dual COX/5-LOX Inhibitor in Intracerebroventricular Streptozotocin-Induced Behavioral and Biochemical Abnormalities in Rats},
  author={Ashok Kumar and Sorabh Sharma and Ashwani Prashar and Rahul Deshmukh},
  journal={Journal of Molecular Neuroscience},
  year={2014},
  volume={55},
  pages={749-759}
}
The present study was designed to investigate the effect of licofelone—a dual cyclooxygenase/5-lipoxygenase (COX/5-LOX) inhibitor in intracerebroventricular streptozotocin (ICV-STZ)-induced cognitive deficit and biochemical abnormalities in rats. ICV-STZ is a widely used model of sporadic Alzheimer’s disease. In this study, STZ was administered… CONTINUE READING