Effect of Laser Prostatectomy on the Serum Prostate-Specific Antigen Concentration: Results of a Prospective Study

  title={Effect of Laser Prostatectomy on the Serum Prostate-Specific Antigen Concentration: Results of a Prospective Study},
  author={A. Kosar and K. Sarıca and E. {\"O}zd{\'i}ler and M. Budak and Ç. Dinçel and Orhan Gogus},
  journal={European Urology},
  pages={193 - 197}
Objective: To assess the effect of the laser prostatectomy (LP) procedure on the serum prostate-specific antigen (PSA) levels. Patient and Methods: The serum PSA level was determined in 41 patients with benign prostatic hyperplasia 1 day before and 1, 3, 7, 15, 30, and 90 days after LP. All patients underwent preoperative evaluation with routine blood tests, serum PSA level, IPSS symptom questionnaire, intravenous pyelography, uroflowmetry, postvoid residual urine measurements, and transrectal… Expand
6 Citations
Changes of serum prostate-specific antigen following high energy thick loop prostatectomy
The reversible increase in serum PSA value is similar to other forms of prostatectomy which, suggests that the increased level of electrosurgical energy that is used in TUVRP does not have an added adverse effect on the PSA levels. Expand
Motexafin Lutetium-Photodynamic Therapy of Prostate Cancer: Short- and Long-Term Effects on Prostate-Specific Antigen
Results show PDT to induce large, transient increases in serum PSA levels, and patients who experienced high PDT dose showed greater short-term increase in PSA and a significantly more durable PSA response (biochemical delay). Expand
Benign prostatic hyperplasia.
A review of recent placebo-controlled trials utilizing phytotherapeutic agents for treatment of BPH and guidelines of German urologists on the diagnosis of benign prostatic hyperplasia. Expand
Prostate specific antigen and benign prostatic hyperplasia
Benign prostatic hyperplasia is a common condition in males over 50 years, but prostate cancer can develop in the same population. Prostate specific antigen, the best marker for prostate cancer, isExpand
Prostate specific antigen and benign prostatic hyperplasia
The better the authors understand the relationships between benign prostatic hyperplasia and prostate specific antigen, the higher will be the discrimination power of prostatespecific antigen measurement as a marker for prostate cancer. Expand
Double‐Layer Nanogold and Poly(amidoamine) Dendrimer‐ Functionalized PVC Membrane Electrode for Enhanced Electrochemical Immunoassay of Total Prostate Specific Antigen
A simple and portable electrochemical immunosensor for the detection of total prostate specific antigen (t-PSA) in human serum was developed using a double-layer nanogold particles andExpand


Clinical implications of the rise and fall of prostate specific antigen after laser prostatectomy.
The pattern of the increase in serum PSA level and decline after VLAP was not predictive of the clinical outcome of therapy. Expand
The effect of digital rectal examination on prostate-specific antigen levels.
No clinically important effects on serum PSA levels were noted after DRE, and the two groups with the highest PSA values were not clinically important as the patients' clinical treatment was not altered. Expand
Effect of cystoscopy, prostate biopsy, and transurethral resection of prostate on serum prostate-specific antigen concentration.
Findings indicate that a serum PSA determination after either a flexible or a rigid cystoscopy is accurate and reliable, and because in some patients the serum P SA still remained elevated after four weeks, it is recommended that a serological determination not be obtained for at least six weeks after either the prostate biopsy or TURP. Expand
Effects of rectal examination, prostatic massage, ultrasonography and needle biopsy on serum prostate specific antigen levels.
It is concluded that digital rectal examination, prostatic massage and ultrasonography have minimal effects on serum PSA levels in most patients, but prostatic needle biopsy usually causes marked elevations of serum PSC levels with a persistent PSA leak into the blood stream lasting longer than expected from the serum half-life of PSA in approximately 25% of the patients. Expand
The effects of transurethral prostatectomy on serum prostate specific antigen.
The failure of the malignant prostate to release PSA in significant amounts during TURP suggests that the elevated levels of PSA found in patients with prostatic carcinoma arise not from the local disease but from its metastases. Expand
Prostate-specific antigen as a serum marker for adenocarcinoma of the prostate.
PSA is more sensitive than PAP in the detection of prostatic cancer and will probably be more useful in monitoring responses and recurrence after therapy, however, since both PSA and PAP may be elevated in benign prostatic hyperplasia, neither marker is specific. Expand
Screening for prostatic carcinoma with prostate specific antigen: results of the second year.
It is concluded that a 20% annual change in PSA level may identify men at significant risk for prostatic carcinoma and that patients so identified have favorable pathological stage. Expand
Screening for prostatic carcinoma with prostate specific antigen.
The usefulness of prostate specific antigen (PSA) in screening for prostatic carcinoma was studied in 262 inpatients of the department of internal medicine and the cancer detection rate was highest for the combination of a suspicious rectal examination and a PSA value > 10 ng/ml. Expand
Laser therapy in dogs and humans--is there a difference?
The canine model gives only an approximate guide to the extent of tissue destruction that laser treatment can achieve in men with BPH, and tissue differences between men may also affect the response to laser treatment. Expand
Prostate specific antigen: a critical assessment of the most useful tumor marker for adenocarcinoma of the prostate.
It is unlikely that PSA by itself will become an effective screening tool for the early diagnosis of prostate cancer, but if combined with digital rectal examination and/or transrectal ultrasound it may become a vital part of any early detection program. Expand