Effect of Ladasten on the Content of Cytokine Markers of Inflammation and Behavior of Mice with Experimental Depression-Like Syndrome

  title={Effect of Ladasten on the Content of Cytokine Markers of Inflammation and Behavior of Mice with Experimental Depression-Like Syndrome},
  author={Anna V Tallerova and L. P. Kovalenko and A. D. Durnev and Sergei B Seredenin},
  journal={Bulletin of Experimental Biology and Medicine},
The effects of ladasten and reference product imipramine (10 mg/kg) on the content of cytokines TNF-α, IL-6, IL-10, IL-1α, IL-2, IL-4, IL-5, IL-17, IFN-γ, and GM-CSF and behavior of male C57Bl/6 mice were studied on the model of a depression-like state induced by a single intraperitoneal injection of bacterial LPS in a dose of 100 μg/kg. Ladasten was injected 5 times in doses of 30 and 50 mg/kg. LPS was administered 1 h after the last injection of the test agents. Behavioral disturbances and… 
Correcting Effect of Ladasten on Variations in the Subpopulation Composition of T Lymphocytes in C57Bl/6 Mice on the Experimental Model of an Anxious-Depressive State
Administration of Ladasten had a normalizing effect on the relative weights of study organs and subpopulation composition of T cells in immunocompetent organs, which returned to the control level.
The Role of Interleukin-17A (IL-17A) in Depression
It may be hypothesized that the IL-17A cytokine plays a key role in the pathogenesis of depression, due to the comorbidity of depression and chronic inflammatory processes, and depression’s effect on the immune system.
Antidepressant activity of astilbin: involvement of monoaminergic neurotransmitters and BDNF signal pathway.
The findings suggest that AST has antidepressant activities and the mechanisms, at least in part, relate to up-regulation of monoaminergic neurotransmitters (5-HT and DA) and activation of the BDNF signaling pathway.
T helper cells in depression: central role of Th17 cells
The major subsets of Th cells known to be involved in neuroimmunology of depression, such as Th1, Th17, and T regulatory cells, are described, with an in-depth discussion on current knowledge about Th17 cells in depression.


Amitriptyline and nortriptyline inhibit interleukin-1 release by rat mixed glial and microglial cell cultures.
The obtained results support the previous observations that antidepressants are able to reduce peripheral release of pro-inflammatory cytokines and suggest that the cytokine network may be involved in the central mechanism of action of amitriptyline and nortripty line.
Cytokine imbalance in the pathophysiology of major depressive disorder
Efavirenz Induces Depressive-Like Behaviour, Increased Stress Response and Changes in the Immune Response in Rats
It is concluded that efavirenz induces depressive-like behaviour in the rat and a susceptibility to stress, which are accompanied by an increase in pro-inflammatory cytokines which are partially alleviated by chronic treatment with paroxetine.
Cytokines and major depression
cDNA macroarray analysis of gene expression changes in rat brain after a single administration of a 2-aminoadamantane derivative
The analysis of hybridization on macroarrays has demonstrated that Ladasten alters the expression of 12 genes in the rat brain, and the changes in their activity explain the mechanisms of the anxiolytic and mood-stabilizing effects of the drug.
Changes in the immune system in depression and dementia: causal or coincidental effects?
Evidence that inflammatory changes in the brain are pathological features of both depression and dementia suggests that an increase in inflammation-induced apoptosis, together with a reductin in the synthesis of neurotrophic factors caused by a rise in brain glucocorticoids, may play a role in the pathology of these disorders.
[DNA macroarray analysis of gene expression changes in rat brain after single administration of 2-aminoadamantane compound].
Assessment of changes in mRNA expression of 588 genes in rat brain after acute treatment of 2-aminoadamantane compound--Ladasten showed that Ladasten induced genes are involved in the different signalling pathways, genes encoding the cytosceletal proteins, synaptic proteins, and metabolism enzymes.
The olfactory bulbectomised rat as a model of depression