Effect of LHRH agonist, Zoladex, on ovarian histology.

  title={Effect of LHRH agonist, Zoladex, on ovarian histology.},
  author={Kelly M Williamson and John F. R. Robertson and Ian O. Ellis and Christopher W. Elston and Robert Ian Nicholson and R. W. Blamey},
  journal={The British journal of surgery},
  volume={75 6},
In a phase I clinical trial Zoladex was used as first line hormonal therapy in premenopausal women with advanced breast cancer. Patients on progression of their disease underwent surgical oöphorectomy. The histology of ovaries from 23 women treated with Zoladex has been compared with the ovaries from 34 patients who, before the clinical trial of Zoladex, underwent surgical oöphorectomy as primary therapy. Both groups show similar follicular phase development. Only 13 per cent of the Zoladex… CONTINUE READING