Effect of L-leucine-supplemented diet on the nicotinamide adenine dinucleotide content of rat liver.

@article{Sakakibara1982EffectOL,
  title={Effect of L-leucine-supplemented diet on the nicotinamide adenine dinucleotide content of rat liver.},
  author={Shigeki Sakakibara and Kenji Fujii and S Nasu and Hiroshi Imai and K Yamaguchi and I Ueda},
  journal={The Journal of nutrition},
  year={1982},
  volume={112 9},
  pages={
          1688-95
        }
}
The hepatic nicotinamide adenine dinucleotide (NAD) content was significantly lower in rats fed a diet supplemented with 0.45-10% L-leucine for 1-3 weeks than in control rats fed laboratory chow (24.6% protein). High dietary levels of leucine did not affect the activity of hepatic tryptophan pyrrolase or quinolinate phosphoribosyltransferase, which are key enzymes in the tryptophan leads to NAD pathway. The increased hepatic NAD contents 4 hours after intraperitoneal injections of the NAD… 
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