Effect of L-leucine-supplemented diet on the nicotinamide adenine dinucleotide content of rat liver.

  title={Effect of L-leucine-supplemented diet on the nicotinamide adenine dinucleotide content of rat liver.},
  author={Shigeki Sakakibara and Kenji Fujii and S Nasu and Hiroshi Imai and K Yamaguchi and I Ueda},
  journal={The Journal of nutrition},
  volume={112 9},
The hepatic nicotinamide adenine dinucleotide (NAD) content was significantly lower in rats fed a diet supplemented with 0.45-10% L-leucine for 1-3 weeks than in control rats fed laboratory chow (24.6% protein). High dietary levels of leucine did not affect the activity of hepatic tryptophan pyrrolase or quinolinate phosphoribosyltransferase, which are key enzymes in the tryptophan leads to NAD pathway. The increased hepatic NAD contents 4 hours after intraperitoneal injections of the NAD… 
The effects of glycine, L-threonine, and L-cystine supplementation to a 9% casein diet on the conversions of L-tryptophan to nicotinamide and to serotonin in rats.
The conversion percentage of L-tryptophan to nicotinamide decreased with the addition of the amino acids glycine, L-threonine and L-cystine to a 9% casein diet, while the concentrations of serotonin in the brain, stomach and small intestine were not affected at all.
Mechanisms of the Pellagragenic Effect of Leucine: Stimulation of Hepatic Tryptophan Oxidation by Administration of Branched-Chain Amino Acids to Healthy Human Volunteers and the Role of Plasma Free Tryptophan and Total Kynurenines
The pellagragenic effect of leucine (Leu) has been proposed to involve modulation of L-tryptophan (Trp) metabolism along the hepatic kynurenine pathway and potential mechanisms of the aggravation of pellagra symptoms by Leu are discussed.
Pellagra and alcoholism: a biochemical perspective.
Pellagra symptoms are resolved by niacin, but aggravated mainly by vitamin B6, and the potential role of 5-ALA and also KA in the skin and neurological disturbances in pellagra should be explored.
International Journal of Tryptophan Research
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