Effect of L-asparaginase combined with vincristine and prednisolone on acute myeloblastic leukemia (M0) associated with non-Hodgkin lymphoma.

Abstract

A 66-year-old Japanese woman was referred to us because of severe anemia and fever and presented at our hospital. She was eventually diagnosed as having acute myeloblastic leukemia (AML; M0) with non-Hodgkin lymphoma (NHL). We investigated the therapeutic efficacy of L-asparaginase (L-Asp), vincristine and prednisolone for both her AML and NHL. Asparagine synthetase (AS) activity in her AML blast cells was undetectable. A lymph node biopsy specimen revealed NHL of the marginal zone B cell type. Complete remission (CR) of AML and NHL was achieved. CR of the AML lasted for 18 months without further consolidation therapy. We conclude that L-Asp can be an effective drug for the treatment of AML in which blasts are negative for AS.

DOI: 10.1159/000243725

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@article{Horikoshi2009EffectOL, title={Effect of L-asparaginase combined with vincristine and prednisolone on acute myeloblastic leukemia (M0) associated with non-Hodgkin lymphoma.}, author={Akira Horikoshi and Kazuhiro Takei and Noriyoshi Iriyama and Kumi Uenogawa and Hikaru Ishizuka and Hidetaka Shiraiwa and Yoshifumi Hosokawa and Shigemasa Sawada and Toshiyuki Kitoh}, journal={Acta haematologica}, year={2009}, volume={122 1}, pages={54-7} }