Effect of L-Dopa and the catechol-O-methyltransferase inhibitor Ro 41-0960 on sulfur amino acid metabolites in rats.

@article{Miller1997EffectOL,
  title={Effect of L-Dopa and the catechol-O-methyltransferase inhibitor Ro 41-0960 on sulfur amino acid metabolites in rats.},
  author={Joshua W. Miller and Barbara Shukitt-Hale and Rafael Villalobos-Molina and Marie R. Nadeau and Jacob Selhub and James Joseph},
  journal={Clinical neuropharmacology},
  year={1997},
  volume={20 1},
  pages={
          55-66
        }
}
L-Dopa is the most effective drug known for the treatment of Parkinson's disease. However, the large doses required to treat this neurodegenerative disorder can significantly affect tissue concentrations of sulfur amino acid metabolites due to peripheral and central O-methylation. These effects include decreases in tissue concentrations of the biochemical methyl donor S-adenosylmethionine (SAM), increases in tissue concentrations of the methylation inhibitor S-adenosylhomocysteine (SAH), and… CONTINUE READING
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