Effect of Kalonji (N. Sativa) Seeds on Glycemic Control of Patients with Type-2 Diabetes

  title={Effect of Kalonji (N. Sativa) Seeds on Glycemic Control of Patients with Type-2 Diabetes},
  author={Shafi M Shaafi and Harish Shrinivas Kulkarni},
  journal={International Journal of Medical Sciences},
The effects of Kalonji (Nigella sativa) on glycemic control and management of newly diagnosed diabetic-2patients was evaluated in this study. The effect of N. Sativa on glycated hemoglobin (HbA1c), fasting blood sugar (FBS), postprandial blood Sugar (PPBS) was examined. Material & Methods: One hundred patients were randomly divided into two groups (n=50 each). Group-1: patients were advised metformin 500 mg twice a day & atorvastatin 10 mg once a day for a period of eight weeks. Group-2: N… 

Tables from this paper


Effect of Nigella Sativa on Lipid Profile in Albino Rats
Background: Coronary heart disease is a global health problem. Dyslipidemia is one of its major risk factors. The purpose of this study was to assess the effect of Nigella sativa seeds in the diet on
The hypoglycemic effect of Nigella sativa oil is mediated by extrapancreatic actions.
The data indicate that the hypoglycemic effect of NSO may be mediated by extrapancreatic actions rather than by stimulated insulin release, and the direct antidiabetic effect of Nigella sativa is not yet established.
Effects of Nigella sativa on oxidative stress and beta-cell damage in streptozotocin-induced diabetic rats.
It is suggested that NS treatment exerts a therapeutic protective effect in diabetes by decreasing oxidative stress and preserving pancreatic beta-cell integrity, and may be clinically useful for protecting beta-cells against oxidative stress.
Effect of Nigella sativa on glucose concentration, lipid peroxidation, anti-oxidant defence system and liver damage in experimentally-induced diabetic rabbits.
It was concluded that N. sativa might be used in diabetic patients to prevent lipid peroxidation, increase anti-oxidant defence system activity and also prevent liver damage.
Nigella sativa L. oil protects against induced hepatotoxicity and improves serum lipid profile in rats.
Nigella sativa L. (NS) oil showed a favourable effect on the serum lipid pattern where the administration of the oil caused a significant decrease in serum total cholesterol, low density lipoprotein, triglycerides and a significant elevation of serum high densitylipoprotein level.
The anti-inflammatory, analgesic and antipyretic activity of Nigella sativa.
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.
Lifestyle changes and treatment with metformin both reduced the incidence of diabetes in persons at high risk and the lifestyle intervention was more effective than meetformin.