Effect of Jak2 kinase inhibition on Stat1 and Stat3 activation and apoptosis of tubular epithelial cells induced by ATP depletion/recovery.

@article{Wang2008EffectOJ,
  title={Effect of Jak2 kinase inhibition on Stat1 and Stat3 activation and apoptosis of tubular epithelial cells induced by ATP depletion/recovery.},
  author={Jianzhong Wang and Chun Ouyang and Xiangmei Chen and Bo Fu and Yang Lu and Quan Hong},
  journal={Journal of nephrology},
  year={2008},
  volume={21 6},
  pages={919-23}
}
BACKGROUND Apoptosis is involved in acute renal failure (ARF). Its exact mechanism still remains to be explored. The Jak-Stat pathway participates in inflammation, apoptosis and tumorigenesis. In an in vitro model of renal ischemia/reperfusion injury (IRI), we investigated the role of Jak2 kinase inhibition on signal transducer and activator of transcription 1 (Stat1) and Stat3 activations as well as apoptosis of human proximal tubular epithelial cells (HKCs) induced by adenosine triphosphate… CONTINUE READING