Effect of JTT-705 on cholesteryl ester transfer protein and plasma lipid levels in normolipidemic animals.

@article{Okamoto2003EffectOJ,
  title={Effect of JTT-705 on cholesteryl ester transfer protein and plasma lipid levels in normolipidemic animals.},
  author={Hiroshi Okamoto and Yoko Iwamoto and Mimi Maki and Tomohiro Sotani and Fumihiko Yonemori and Korekiyo Wakitani},
  journal={European journal of pharmacology},
  year={2003},
  volume={466 1-2},
  pages={147-54}
}
This study evaluated JTT-705, S-[2-([[1-(2-ethylbutyl)cyclohexyl]carbonyl]amino)phenyl]2-methylpropanethioate, as a cholesteryl ester transfer protein (CETP) inhibitor in several animal species. In vitro, JTT-705 inhibited plasma CETP activities of humans, rabbits, hamsters, cynomolgus monkeys and marmosets with IC(50) values of 5.5, 1.0, 11.7, 2.4 and 6.3… CONTINUE READING