Effect of JNK inhibition on cisplatin-induced renal damage.

  title={Effect of JNK inhibition on cisplatin-induced renal damage.},
  author={Helo{\'i}sa Della Coletta Francescato and Roberto Silva Costa and Fernando Barbosa J{\'u}nior and Terezila Machado Coimbra},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  volume={22 8},
BACKGROUND Cisplatin therapy is effective against many tumours, however, the nephrotoxicity of this drug is a dose-limiting factor. Apoptosis and necrosis of tubular cells and inflammatory events contribute to the cisplatin-induced nephrotoxicity. Cisplatin promotes increased production of reactive oxygen species, which can activate c-jun N-terminal kinase (JNK) that is a mediator of apoptosis and can lead to increased expression of proinflammatory mediators that could intensify the cytotoxic… CONTINUE READING