Effect of Ivermectin on Function of Liver Macrophages

@article{Viktorov2004EffectOI,
  title={Effect of Ivermectin on Function of Liver Macrophages},
  author={A. V. Viktorov and V. A. Yurkiv},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2004},
  volume={136},
  pages={569-571}
}
Ivermectin had no effect on phagocytic function of liver macrophages, but blocked LPS-induced secretion of tumor necrosis factor, NO, prostaglandin E2, and increase of intracellular concentration of Ca2+. These inhibitory effects were observed only in the presence of chlorine ions in the extracellular medium, which attested to involvement of glycine-dependent chlorine channels. 
Ivermectin inhibits LPS-induced production of inflammatory cytokines and improves LPS-induced survival in mice
TLDR
Ivermectin improved mouse survival rate induced by a lethal dose of LPS and significantly decreased the production of TNF-α, IL-1ß and IL-6 in vivo and in vitro, and suppressed NF-kB translocation induced by LPS.
Effect of avermectin on the ultrastructural characteristics of loach embryos
TLDR
The ultrastructure of loach (Misgurnus fossilis L.) embryo cells at the stages of the first and tenth blastomere divisions in the presence of avermectin B in an incubation medium at concentrations of 0.01, 0.1, and 1.0 μg/ml was studied.
Avermectin Derivatives, Pharmacokinetics, Therapeutic and Toxic Dosages, Mechanism of Action, and Their Biological Effects
TLDR
Avermectins are a group of drugs that occurs naturally as a product of fermenting Streptomyces avermitilis, an actinomycetes, isolated from the soil and are used for treatment of several metabolic disorders.
Ivermectin: A Review in Rosacea
  • E. Deeks
  • Medicine
    American Journal of Clinical Dermatology
  • 2015
TLDR
Ivermectin 1 % cream is an effective and well tolerated option for the topical treatment of inflammatory lesions of rosacea, with the convenience of once-daily application.
Fungus Metarhizium robertsii and neurotoxic insecticide affect gut immunity and microbiota in Colorado potato beetles
TLDR
The results of this study suggest that fungal infection modulates physiological responses to avermectins and thatFungal infection may increase avertmectin toxicosis by blocking detoxification enzymes in the gut.
A short history of insecticides
TLDR
It is concluded, that an agreeable interaction of scientists and manufacturers of insecticides should lead to the selection of the most optimal solutions for insect pest control, which would be safe, affordable, and effective at the same time.
Pesticides and environmental ecology

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D Dietary glycine is protective in rat models against endotoxemia, liver ischemia-reperfusion, and liver transplantation, most likely by inactivating the Kupffer cell via this newly identified glycine-gated chloride channel.
CELLS OF THE HEPATIC SINUSOID, VOL 3