Effect of Ionic Diffusion on Extracellular Potentials in Neural Tissue

@article{Halnes2016EffectOI,
  title={Effect of Ionic Diffusion on Extracellular Potentials in Neural Tissue},
  author={G. Halnes and T. M{\"a}ki-Marttunen and D. Keller and Klas H. Pettersen and O. Andreassen and G. Einevoll},
  journal={PLoS Computational Biology},
  year={2016},
  volume={12}
}
Recorded potentials in the extracellular space (ECS) of the brain is a standard measure of population activity in neural tissue. Computational models that simulate the relationship between the ECS potential and its underlying neurophysiological processes are commonly used in the interpretation of such measurements. Standard methods, such as volume-conductor theory and current-source density theory, assume that diffusion has a negligible effect on the ECS potential, at least in the range of… Expand
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TLDR
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TLDR
The edNEG model is presented, which is believed to be the first model to combine multicompartmental neuron modeling with an electrodiffusive framework for intra- and extracellular ion concentration dynamics in a local piece of neuro-glial brain tissue, and ensures a complete and consistent relationship between ion concentrations and charge conservation. Expand
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