Effect of Intestinal Microflora on the Production of Interleukin 10 and Prostaglandin E2 in Serum and Kupffer Cells from Germfree and Conventional Mice

@article{Ikeda2007EffectOI,
  title={Effect of Intestinal Microflora on the Production of Interleukin 10 and Prostaglandin E2 in Serum and Kupffer Cells from Germfree and Conventional Mice},
  author={Masamichi Ikeda and Hideo Ohira and Yukiko Toyama and Tikae Katagiri and Bunsaku Sakakibara},
  journal={Journal of Clinical Biochemistry and Nutrition},
  year={2007},
  volume={41},
  pages={169 - 174}
}
To determine why germfree (GF) mice are less productivity of proinflammatory cytokines than conventional (CV) mice, we studied serum levels of interleukin 10 (IL-10) and prostaglandin E(2) (PGE(2)) in mice after treatment with lipopolyssacharide (LPS). A single injection of LPS caused an elevation of IL-10 in serum from GF, LPS-GF (germfree mice given drinking water containing LPS) and CV mice. The response was highest in serum from GF mice, and was lower in serum from LPS-GF mice compared with… CONTINUE READING

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