Effect of Ingested Lipids on Drug Dissolution and Release with Concurrent Digestion: A Modeling Approach

@article{Buyukozturk2013EffectOI,
  title={Effect of Ingested Lipids on Drug Dissolution and Release with Concurrent Digestion: A Modeling Approach},
  author={Fulden Buyukozturk and Selena Di Maio and David Budil and Rebecca Lyn Carrier},
  journal={Pharmaceutical Research},
  year={2013},
  volume={30},
  pages={3131-3144}
}
To mechanistically study and model the effect of lipids, either from food or self-emulsifying drug delivery systems (SEDDS), on drug transport in the intestinal lumen. Simultaneous lipid digestion, dissolution/release, and drug partitioning were experimentally studied and modeled for two dosing scenarios: solid drug with a food-associated lipid (soybean oil) and drug solubilized in a model SEDDS (soybean oil and Tween 80 at 1:1 ratio). Rate constants for digestion, permeability of emulsion… CONTINUE READING