Effect of Indian Ayurvedic medicine Ashwagandha on measurement of serum digoxin and 11 commonly monitored drugs using immunoassays: study of protein binding and interaction with Digibind.

@article{Dasgupta2007EffectOI,
  title={Effect of Indian Ayurvedic medicine Ashwagandha on measurement of serum digoxin and 11 commonly monitored drugs using immunoassays: study of protein binding and interaction with Digibind.},
  author={Amitava Dasgupta and Amanda Peterson and Alice Wells and Jeffrey K. Actor},
  journal={Archives of pathology \& laboratory medicine},
  year={2007},
  volume={131 8},
  pages={
          1298-303
        }
}
CONTEXT Ashwagandha, a popular Ayurvedic medicine, is now available in the United States. Alkaloids found in this herb have structural similarity with digoxin. OBJECTIVE To study potential interference of Ashwagandha with serum digoxin measurement by immunoassays. Potential interference was also investigated with immunoassays for 11 other commonly monitored drugs. In addition, interaction of components of Ashwagandha with the Fab fragment of antidigoxin antibody (Digibind) was investigated… 

Tables from this paper

Effect of Asian ginseng, Siberian ginseng, and Indian ayurvedic medicine Ashwagandha on serum digoxin measurement by digoxin III, a new digoxin immunoassay

Measuring free digoxin does not eliminate the modest interferences of these herbal supplements in serum digoxin measurement by the Digoxin III assay, and the results with the values obtained by Tina‐quant assay are compared.

Monitorización terapéutica de la digoxina en pacientes con insuficiencia cardíaca: comparación entre dos métodos analíticos

LC-MS/MS is safer, more selective and specific than immunoassay, being an option for therapeutic drug monitoring of digoxin, since the reference values would be obtain for digoxinemia by LC- MS/MS.

DIPEPTIDYL PEPTIDASE-IV INHIBITION AND EX-VIVO ANTIOXIDANT POTENTIAL OF PHYTOCOMPOUNDS OF WITHANIA SOMNIFERA, TRIGONELLA FOENUM AND BAUHINIA PURPUREA

The result of present study reveals that extracts of WS and TFG contains novel DPP-IV inhibitors with antiperoxidative potential and can be developed as therapeutic molecules for type 2 diabetes mellitus.

Herbal and Dietary Supplement–Drug Interactions in Patients Taking Digoxin

The evidence about the interaction between herbal-dietary supplements and digoxin is reviewed and it is recommended that the use of these herbs with digoxin be avoided.

Ashwagandha (Withania somnifera) – a herb with versatile medicinal properties empowering human physical and mental health

The plant has also been widely studied for its various pharmacological activities like antioxidant, anxiolytic, adaptogen, memory enhancing, antiparkinsonian, antiinflammatory, antitumor properties.

insuficiencia cardiaca: comparación entre dos métodos analíticos

LC- MS/MS is safer, more selective and specific than immunoassay, being an option for therapeutic drug monitoring of digoxin, since the reference values would be obtain for digoxinemia by LC-MS/MS.

[Therapeutic drug monitoring of digoxin in cardiac heart failure outpatients: comparisons of two analytical methods].

It was concluded that LC-MS/MS is safer, more selective and specific than immunoassay, being an option for therapeutic drug monitoring of digoxin, since the reference values would be obtain for digoxinemia by LC- MS/MS.

A Comprehensive Review of Recent Studies on Herb-Drug Interaction: A Focus on Pharmacodynamic Interaction.

The number of HDI reports has gradually increased since 2000, with a primary focus on neoplasms an...

References

SHOWING 1-10 OF 16 REFERENCES

Effect of Chinese Medicines Chan Su and Danshen on EMIT 2000 and Randox Digoxin Immunoassays: Wide Variation in Digoxin-like Immunoreactivity and Magnitude of Interference in Digoxin Measurement by Different Brands of the Same Product

It is demonstrated that interference of Chan Su in EMIT 2000 and Randox assays can be mostly eliminated by monitoring free digoxin, indicating poor quality control in manufacturing of these Chinese medicines.

Effect of Asian and Siberian ginseng on serum digoxin measurement by five digoxin immunoassays. Significant variation in digoxin-like immunoreactivity among commercial ginsengs.

Digoxin-like immunoreactive substances (DLISs) showed synergistic effects with ginsengs in interfering with the FPIA and MEIA for digoxin, and no interference was observed with 3 other digoxin assays, even in the presence of elevated DLISs.

Efficacy of digoxin specific Fab fragments (Digibind) in the treatment of toad venom poisoning.

Effect of the traditional chinese medicines Chan Su, Lu‐Shen‐Wan, Dan Shen, and Asian Ginseng on Serum Digoxin measurement by Tina‐quant (Roche) and Synchron LX system (Beckman) digoxin immunoassays

The FPIA showed the most significant interference from all four of the Chinese medicines the authors studied, which can have additive effects with these Chinese medicines and falsely increase apparent digoxin levels by the FPIA.

Digoxin assays: frequent, substantial, and potentially dangerous interference by spironolactone, canrenone, and other steroids.

The frequency and magnitude of the false-negative results particularly compromise the use of both microparticle enzyme immunoassays and may toxic concentrations remain unidentified, but intoxication could occur should dosage be increased because of falsely low results.

Therapeutic Monitoring of Digoxin and Antiepileptic Drugs in Egypt and Saudi Arabia

When the levels of all drugs relative to therapeutic ranges were compared between the 1996 and 2001 Saudi data, a significant decrease in the rate of potentially toxic levels was seen in 2001.

Beneficial effect of digoxin-specific Fab antibody fragments in oleander intoxication.

The value of digoxin-specific Fab antibody fragments in the treatment of plant glycoside and, in particular, oleander intoxication is discussed.

Immunoassay of estradiol: unanticipated suppression by unconjugated estriol.

A negative interference of unconjugated estriol with the MEIA method is a source of error for estradiol measurement, and Lack of specificity and lack of comparability among immunoassay methods forEstradiol may have detrimental effects on medical practice.

Monograph. Withania somnifera.

  • Withania somnifera
  • Medicine
    Alternative medicine review : a journal of clinical therapeutic
  • 2004
Clinical trials and animal research support the use of ashwaganda for anxiety, cognitive and neurological disorders, inflammation, and Parkinson’s disease, and its chemopreventive properties make it a potentially useful adjunct for patients undergoing radiation and chemotherapy.