Effect of Increasing the Copy Number of Bacteriophage Origins of Replication, in trans, on Incoming-Phage Proliferation.

@article{Osullivan1993EffectOI,
  title={Effect of Increasing the Copy Number of Bacteriophage Origins of Replication, in trans, on Incoming-Phage Proliferation.},
  author={D J O'sullivan and C. Ray Hill and Todd R. Klaenhammer},
  journal={Applied and environmental microbiology},
  year={1993},
  volume={59 8},
  pages={2449-56}
}
Bacteriophage resistance mechanisms which are derived from a bacteriophage genome are termed Per (phage-encoded resistance). When present in trans in Lactococcus lactis NCK203, Per50, the cloned origin of replication from phage phi50, interferes with phi50 replication. The per50 fragment was found to afford negligible protection to NCK203 against phi50… CONTINUE READING