Effect of If-channel inhibition on hemodynamic status and exercise tolerance in heart failure with preserved ejection fraction: a randomized trial.

@article{Kosmala2013EffectOI,
  title={Effect of If-channel inhibition on hemodynamic status and exercise tolerance in heart failure with preserved ejection fraction: a randomized trial.},
  author={Wojciech Kosmala and David James Holland and Aleksandra Rojek and Leah Wright and Monika Przewlocka-Kosmala and Thomas H Marwick},
  journal={Journal of the American College of Cardiology},
  year={2013},
  volume={62 15},
  pages={1330-8}
}
OBJECTIVES The aim of this study was to test the effects of treatment with ivabradine on exercise capacity and left ventricular filling in patients with heart failure with preserved ejection fraction (HFpEF). BACKGROUND Because symptoms of HFpEF are typically exertional, optimization of diastolic filling time by controlling heart rate may delay the onset of symptoms. METHODS Sixty-one patients with HFpEF were randomly assigned to ivabradine 5 mg twice daily (n = 30) or placebo (n = 31) for… CONTINUE READING
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