Effect of Hyperhomocysteinemia on Redox Balance and Redox Defence Enzymes in Ischemia–Reperfusion Injury and/or After Ischemic Preconditioning in Rats

@article{Petr2017EffectOH,
  title={Effect of Hyperhomocysteinemia on Redox Balance and Redox Defence Enzymes in Ischemia–Reperfusion Injury and/or After Ischemic Preconditioning in Rats},
  author={Martin Petr{\'a}{\vs} and Anna Drgov{\'a} and M{\'a}ria Kovalsk{\'a} and Zuzana Tatarkov{\'a} and Barbara T{\'o}thov{\'a} and Oľga Kri{\vz}anov{\'a} and J{\'a}n Lehotsk{\'y}},
  journal={Cellular and Molecular Neurobiology},
  year={2017},
  volume={37},
  pages={1417-1431}
}
  • Martin Petráš, Anna Drgová, +4 authors Ján Lehotský
  • Published in Cellular and Molecular Neurobiology 2017
  • DOI:10.1007/s10571-017-0473-5
Increased level of homocysteine (hHcy) in plasma is an accompanying phenomenon of many diseases, including a brain stroke. This study determines whether hyperhomocysteinemia (which is a risk factor of brain ischemia) itself or in combination with ischemic preconditioning affects the ischemia-induced neurodegenerative changes, generation of reactive oxygen species (ROS), lipoperoxidation, protein oxidation, and activity of antioxidant enzymes in the rat brain cortex. The hHcy was induced by… CONTINUE READING

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