Effect of Hypercholesterolemia on Expression and Function of Vascular Soluble Guanylyl Cyclase

  title={Effect of Hypercholesterolemia on Expression and Function of Vascular Soluble Guanylyl Cyclase},
  author={Ute Laber and T. Kober and V. Schmitz and A. Schrammel and W. Meyer and Bernd Mayer and M. Weber and G. Kojda},
  journal={Circulation: Journal the of American Heart Association},
  • Ute Laber, T. Kober, +5 authors G. Kojda
  • Published 2002
  • Medicine
  • Circulation: Journal the of American Heart Association
  • Background—Vasorelaxation to endothelial NO is mediated by activation of soluble guanylyl cyclase (sGC) and impaired by hypercholesterolemia in animals and humans. We investigated whether hypercholesterolemia impacts expression and function of sGC. Methods and Results—White New Zealand rabbits (n=10 per group) received a standard diet for 16 weeks (SD16) (n=20) or 32 weeks (SD32) and a cholesterol diet (7.5 g/kg) for 16 weeks (CD16) (n=20) or 32 weeks (CD32), respectively. Another group… CONTINUE READING
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