• DOI:10.1161/HC0702.103975
Corpus ID: 3079385

Effect of Hypercholesterolemia on Expression and Function of Vascular Soluble Guanylyl Cyclase

@article{Laber2002EffectOH,
  title={Effect of Hypercholesterolemia on Expression and Function of Vascular Soluble Guanylyl Cyclase},
  author={Ute Laber and T. Kober and V. Schmitz and A. Schrammel and W. Meyer and Bernd Mayer and M. Weber and G. Kojda},
  journal={Circulation: Journal the of American Heart Association},
  year={2002},
  volume={105},
  pages={855-860}
}

Ute Laber, T. Kober, +5 authors G. Kojda

Published 2002

Medicine

Circulation: Journal the of American Heart Association

Background—Vasorelaxation to endothelial NO is mediated by activation of soluble guanylyl cyclase (sGC) and impaired by hypercholesterolemia in animals and humans. We investigated whether hypercholesterolemia impacts expression and function of sGC. Methods and Results—White New Zealand rabbits (n=10 per group) received a standard diet for 16 weeks (SD16) (n=20) or 32 weeks (SD32) and a cholesterol diet (7.5 g/kg) for 16 weeks (CD16) (n=20) or 32 weeks (CD32), respectively. Another group… CONTINUE READING

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